Wnt Signaling Pathway Inhibitors Therapeutics Pipeline to Witness Numerous Collaborations in Future
Dec 5, 2017
Wnt signaling pathway inhibitors therapeutics pipeline comprises of approximately 26 drug candidates in different stages of development, Published by P&S Market Research.
Ave - December 5, 2017 /MarketersMedia/ —
The study analyzed that the Wnt signaling pathway inhibitors therapeutics pipeline comprises approximately 26 drug candidates in different stages of development. Wnt or β-Catenin signaling pathway plays an important role in the development of pluripotent cells. The signaling pathway was earlier named as Wingless (Wng) in Drosophila and Int1 in the mouse. Wnt proteins consist of several glycoproteins that have conserved cysteine residues. There are 19 human Wnt genes that encode spliced isoforms. Wnt proteins bind to the Frizzled (Fz) receptors which forms the complex with low-density lipoprotein receptor-related protein (LRP).
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According to the Center for Disease Control and Prevention (CDC), more than 1.5 million cases of invasive cancer, including about 15,000 cases among children younger than 20 years, and more than 590,000 deaths from cancer, are reported every year in the U.S. The rising prevalence of cancer is a major factor driving the pipeline, since Wnt signaling pathway has been recognized in the development of cancer cells.
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The positive clinical results of Wnt signaling pathway inhibitors drug candidates are driving the pipeline growth. Samumed, LLC announced the successful completion of a 52-week Phase II clinical trial of its potential treatment for osteoarthritis of the knee.
In July 2017, Oncology Venture AB and 2X Oncology, Inc. entered into an exclusive global license agreement with Eisai Inc. for Eisai's Phase II PARP inhibitor E7449 - now called 2X-121. 2X-121 would be developed by 2X Oncology, Inc., a precision medicine company developing targeted therapeutics to address significant unmet needs in women's cancer.
Some of the key players developing drugs for the treatment of Wnt signaling pathway inhibitors therapeutics include Samumed, LLC, Can-Fite BioPharma Ltd., Tactical Therapeutics, Inc. and others.
Wnt Signaling Pathway Inhibitors Therapeutics Pipeline Analysis
• By Phase
• By Molecule Type
• By Route of Administration
• By Company
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Prostatitis Therapeutics Pipeline, 2017
The study analyzed that the prostatitis therapeutics pipeline comprises 11 drug candidates in different stages of development. Prostatitis is an infection or inflammation of the prostate gland that can lead to various syndromes with varying clinical features. The term prostatitis is defined as microscopic inflammation of the tissue of the prostate gland and it occurs due to a broad range of clinical conditions. The National Institutes of Health (NIH) has recognized and defined a classification system for prostatitis in 1999.
https://www.psmarketresearch.com/market-analysis/prostatitis-therapeutics-pipeline
Progressive Supranuclear Palsy (PSP) Therapeutics Pipeline Analysis, 2017
The study analyzed that PSP therapeutics pipeline comprises approximately 14 drug candidates in different stages of development. The exact cause of PSP is unknown, but it has been observed that PSP is the accumulation of abnormal deposits of the tau protein in nerve cells in the brain, and eventual toxicity in nerve cells in the brain stem. The appearance of deposits of the microtubule-associated tau protein termed ‘neurofibrillary tangles’ is a common feature of tauopathies and development of progressive supranuclear palsy.
https://www.psmarketresearch.com/market-analysis/psp-pipeline-analysis
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